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GHRP-2 Research Profile

Research Use

GHRP-2 (Pralmorelin) is a synthetic hexapeptide Growth Hormone Releasing Peptide. It produces robust GH pulses through GHSR agonism, with moderate cortisol and prolactin elevation. It sits between the potency of GHRP-6 and the clean selectivity of Ipamorelin.

GHRP-2 Quick Technical Specifications

Category
Growth Hormone Secretagogue
Elimination Half-Life
approx. 2 to 6 hours
Storage Protocol
Refrigerated (2°C-8°C)
Status
Research Use
OE
Written by OnePeptideShip Editorial Team
Reviewed by Dr. Aris Thorne, MD, Board Certified Endocrinology Advisor
Updated September 2026

Mechanism of Action & Biochemical Context

GHRP-2 (Pralmorelin) is a synthetic hexapeptide Growth Hormone Releasing Peptide. It produces robust GH pulses through GHSR agonism, with moderate cortisol and prolactin elevation. It sits between the potency of GHRP-6 and the clean selectivity of Ipamorelin.

Storage, Reconstitution & Stability Guidelines

Prior to reconstitution, lyophilized GHRP-2 powder should be stored away from light between 2°C and 8°C for short-term access, or -20°C for long-term preservation. Once reconstituted with Bacteriostatic Water (0.9% benzyl alcohol preservative), maintain strict refrigeration between 2°C and 8°C. Do not freeze liquid solution.

Cited Scientific References

  1. Bowers CY. GH releasing peptides - structure and kinetics. J Pediatr Endocrinol. 1993.

Calculate GHRP-2 Syringe Units

Input your vial mg and BAC water mL to calculate exact U-100 draw units.

Open GHRP-2 Calculator →

Frequently Asked Questions

Drawing 4 units (0.04mL) on an insulin syringe is very difficult due to dead space and scale. The most practical solution is to add more water to the vial. Adding 4mL of BAC water to a 5mg vial creates a 1,250mcg/mL solution, making a 100mcg dose exactly 8 units - easier to draw accurately. Use the calculator with 4mL water entered for your adjusted unit draw.

Research indicates that approximately 100-150mcg per injection maximally saturates the GHSR in humans. Doses above 200mcg produce only marginally stronger GH pulses while disproportionately increasing the cortisol and prolactin response. There is minimal benefit to exceeding 150mcg per injection.

GHRP-2 produces a larger total GH pulse than Ipamorelin at equivalent doses, but it is "dirtier" - it elevates cortisol and prolactin to a moderate degree, and causes some appetite stimulation. Ipamorelin produces a cleaner, more selective GH release with virtually no cortisol or prolactin elevation. For long-term use, Ipamorelin is preferred; for maximum short-term GH output (e.g., intense athletic research), GHRP-2 is chosen.

Yes - this is one of the most common GH-optimization stacks in research. CJC-1295 No DAC (the GHRH signal) combined with GHRP-2 (the GHSR signal) creates a synergistic GH pulse that is exponentially greater than either compound alone. Mix them into the same syringe for a single, convenient injection on an empty stomach.

Moderately. GHRP-2 binds to the ghrelin receptor, which regulates appetite. Subjects often report a mild-to-moderate increase in hunger within 30-60 minutes of injection. This is less severe than GHRP-6 (which causes ravenous, uncontrollable hunger) but more pronounced than Ipamorelin (minimal hunger effect). Timing injections before meals can turn this into a useful pre-meal appetite primer.

The three optimal windows, in order of importance: (1) Before bed - coincides with the largest natural GH pulse during slow-wave sleep; (2) Morning - on an empty stomach upon waking to prime daytime GH levels; (3) Post-workout - GH is naturally elevated after exercise; GHRP-2 amplifies this pulse further. All injections must be in a fasted state (2+ hours post-meal, 30 minutes pre-meal).

The main long-term concern is chronic mild elevation of cortisol and prolactin. While the elevation per injection is modest, running GHRP-2 three times daily for months can contribute to cumulative cortisol load. Periodic blood tests (every 3 months) checking prolactin, IGF-1, and cortisol are recommended. Many researchers cycle to Ipamorelin after 12-16 weeks of GHRP-2 to give receptors and hormonal axes a rest.