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CJC-1295 Research Profile

Research Use

CJC-1295 is a tetrasubstituted 29-amino acid Growth Hormone-Releasing Hormone (GHRH) analog. It stimulates the pituitary to produce and release endogenous Growth Hormone in pulsatile bursts, preserving natural feedback loops.

CJC-1295 Quick Technical Specifications

Category
GHRH Secretagogue
Elimination Half-Life
30 minutes (without DAC) / 6 to 8 days (with DAC)
Storage Protocol
Refrigerated (2°C-8°C)
Status
Research Use
OE
Written by OnePeptideShip Editorial Team
Reviewed by Dr. Aris Thorne, MD, Board Certified Endocrinology Advisor
Updated September 2026

Mechanism of Action & Biochemical Context

CJC-1295 is a tetrasubstituted 29-amino acid Growth Hormone-Releasing Hormone (GHRH) analog. It stimulates the pituitary to produce and release endogenous Growth Hormone in pulsatile bursts, preserving natural feedback loops.

Storage, Reconstitution & Stability Guidelines

Prior to reconstitution, lyophilized CJC-1295 powder should be stored away from light between 2°C and 8°C for short-term access, or -20°C for long-term preservation. Once reconstituted with Bacteriostatic Water (0.9% benzyl alcohol preservative), maintain strict refrigeration between 2°C and 8°C. Do not freeze liquid solution.

Cited Scientific References

  1. Teichman SL, et al. Prolonged stimulation of GH secretion by CJC-1295. J Clin Endocrinol Metab. 2006.

Calculate CJC-1295 Syringe Units

Input your vial mg and BAC water mL to calculate exact U-100 draw units.

Open CJC-1295 Calculator →

Frequently Asked Questions

No DAC (also called Modified GRF 1-29 or Mod GRF) has a half-life of roughly 30 minutes, creating a sharp, natural-like pulse of GH. It is dosed daily. With DAC adds a Drug Affinity Complex that allows it to bind to albumin, extending the half-life to approximately 8 days, creating a continuous, steady release of GH. It is dosed 1-2 times per week. No DAC is preferred for most anti-aging and recovery research because it preserves the natural pulsatile rhythm of GH.

Using the standard 2mg vial with 2mL of BAC water (concentration: 1,000mcg/mL): 100mcg = 0.1mL = 10 units on a U-100 syringe. This is a clean, easy-to-draw volume.

Yes, and it is highly recommended. Both peptides should be administered at exactly the same time for maximum GH synergy. Pull your CJC-1295 dose (e.g., 10 units) into the syringe first, then pull your Ipamorelin dose (e.g., 20 units for 200mcg) into the same syringe. You get a single injection with an exponentially enhanced GH pulse.

Carbohydrates and fats spike insulin levels. Insulin and Growth Hormone operate on a counter-regulatory seesaw: when insulin is high, GH is suppressed. Injecting CJC-1295 with high insulin means the pituitary receives the GHRH signal but the downstream GH pulse is blunted or eliminated by insulin antagonism. You must be in a fasted state (2+ hours post-meal) for the injection to be effective.

100mcg per injection, administered 1-3 times daily. The most critical time is right before bed, as this coincides with the body's largest natural GH pulse during slow-wave sleep. Pre-workout and upon waking are additional dosing windows. Each injection must be done on an empty stomach.

No, this is its key safety advantage over synthetic HGH. CJC-1295 works within the body's existing feedback loop - when GH levels rise too high, the pituitary naturally produces somatostatin to inhibit further release. This self-limiting mechanism makes CJC-1295 much safer than injectable HGH, which overrides this feedback completely.

Most researchers run CJC-1295 for 12 to 24 weeks for meaningful anti-aging and body composition results, as GH secretagogue effects accumulate slowly. Cycles can be run continuously (especially with No DAC due to its short half-life and natural pulse pattern) or in 16-week-on, 4-week-off cycles.